Optimization of pharmaco-chemical in vitro screening process : Cell-based impedance application for ECIS platform
The ECIS® platform, is the perfect tool to discover the drugs of tomorrow and makes real gain of productivity in R&D process.
The realization of pharmacological and chemical screening with the ECIS® platform starts by getting a “screening reference” (positive control). The reference for a screening is the dynamic mapping of cellular events obtained in real time. This dynamic mapping is materialized by the impedance curves obtained during the test.
Performing a screening with the ECIS® platform has major advantages :
- Only the effect of the screened molecules is observed.
- The screening process is in real time, on living cells and label free, then you have a total control on the test you performed
- It offers the sensitivity and robustness required in any screening process.
After the screening process, ECIS® platform could then be used for in vitro toxicology studies (see page toxicology).
The platform is a real gain of productivity for R&D helping for GoNoGo decision.
High-content screening imaging and real-time cellular impedance monitoring for the assessment of chemical's bio-activation with regards hepatotoxicity Journal Article
Toxicol In Vitro., 29 (7), pp. 1916-1931, 2015.
BK/TD models for analyzing in vitro impedance data on cytotoxicity Journal Article
Toxicol Lett., 235 (2), pp. 96-106, 2015, ( ).